منابع مشابه
Unveiling the molecular clock in the presence of recombination.
In a recent letter in Molecular Biology and Evolution, Schierup and Hein (2000a) showed that the likelihood ratio test (LRT) of the molecular clock (Felsenstein 1981) ‘‘wrongly’’ rejects the clock hypothesis when recombination has occurred. However, this result should not be taken as a failure of the LRT. Because in the presence of recombination often there is not one single tree describing the...
متن کاملOn the overdispersed molecular clock.
Rates of molecular evolution at some loci are more irregular than described by simple Poisson processes. Three situations under which molecular evolution would not follow simple Poisson processes are reevaluated from the viewpoint of the neutrality hypothesis: concomitant or multiple substitutions in a gene, fluctuating substitution rates in time caused by coupled effects of deleterious mutatio...
متن کاملVagaries of the molecular clock.
The hypothesis of the molecular evolutionary clock asserts that informational macromolecules (i.e., proteins and nucleic acids) evolve at rates that are constant through time and for different lineages. The clock hypothesis has been extremely powerful for determining evolutionary events of the remote past for which the fossil and other evidence is lacking or insufficient. I review the evolution...
متن کاملCalibrating the avian molecular clock.
Molecular clocks are widely used to date phylogenetic events, yet evidence supporting the rate constancy of molecular clocks through time and across taxonomic lineages is weak. Here, we present 90 candidate avian clock calibrations obtained from fossils and biogeographical events. Cross-validation techniques were used to identify and discard 16 inconsistent calibration points. Molecular evoluti...
متن کاملUnderstanding the overdispersed molecular clock.
Rates of molecular evolution at some protein-encoding loci are more irregular than expected under a simple neutral model of molecular evolution. This pattern of excessive irregularity in protein substitutions is often called the "overdispersed molecular clock" and is characterized by an index of dispersion, R(T) > 1. Assuming infinite sites, no recombination model of the gene R(T) is given for ...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2000
ISSN: 1537-1719,0737-4038
DOI: 10.1093/oxfordjournals.molbev.a026256